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Resolving the cadherin–F-actin connection

Nature Cell Biology volume 19, pages 1416 (2017) | Download Citation

Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and biochemical signals.

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Author information

Affiliations

  1. Mitchell K. L. Han and Johan de Rooij are at the Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands

    • Mitchell K. L. Han
    •  & Johan de Rooij

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Johan de Rooij.

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DOI

https://doi.org/10.1038/ncb3457

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