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Resolving the cadherin–F-actin connection

Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and biochemical signals.

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Figure 1: Mechanochemical regulation of vinculin within the cadherin/F-actin interface.

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Correspondence to Johan de Rooij.

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Han, M., de Rooij, J. Resolving the cadherin–F-actin connection. Nat Cell Biol 19, 14–16 (2017). https://doi.org/10.1038/ncb3457

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