A powerful combination of two-colour imaging in vivo, Fourier-filtered kymography and simulations provides a high-resolution view of kinesin-2 transport dynamics in cilia. This study reveals heterotrimeric kinesin-II as an 'obstacle-course runner' and homodimeric OSM-3 (KIF17) as a 'long-distance runner', and elucidates the 'baton handoff' between these two kinesin-2 motors on the microtubule track.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Rosenbaum, J. L. & Witman, G. B. Nat. Rev. Mol. Cell Biol. 3, 813–825 (2002).
Snow, J. J. et al. Nat. Cell Biol. 6, 1109–1113 (2004).
Prevo, B. et al. Nat. Cell Biol. 17, 1536–1545 (2015).
Mallik, R. et al. Trends Cell Biol. 23, 575–582 (2013).
Perkins, L. A., Hedgecock, E. M., Thomson, J. N. & Culotti, J. G. Dev. Biol. 117, 456–487 (1986).
Reiter, J. F., Blacque, O. E. & Leroux, M. R. EMBO Rep. 13, 608–618 (2012).
Hoeprich, G. J. et al. Biophys. J. 106, 1691–1700 (2014).
Burghoorn, J. et al. Proc. Natl Acad. Sci. USA 104, 7157–7162 (2007).
Liang, Y. et al. Dev. Cell 30, 585–597 (2014).
Williams, C. L. et al. Nat. Commun. 5, 5813 (2014).
O'Hagan, R. et al. Curr. Biol. 21, 1685–1694 (2011).
Ou, G. et al. Nature 436, 583–587 (2005).
Morsci, N. S. & Barr, M. M. Curr. Biol. 21, 1239–1244 (2011).
Jenkins, P. M. et al. Curr. Biol. 16, 1211–1216 (2006).
Jiang, L. et al. Faseb J. http://dx.doi.org/10.1096/fj.15-275677 (2015).
Niwa, S. Anat. Sci. Int. 90, 1–6 (2015).
Acknowledgements
The authors are supported by NJCSCR grant CSCR15IRG014 (R.O.) and NIH grants DK059418 and DK074746 (M.B.).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
O'Hagan, R., Barr, M. A motor relay on ciliary tracks. Nat Cell Biol 17, 1517–1519 (2015). https://doi.org/10.1038/ncb3279
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3279
