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A centrosomal route for cancer genome instability

Nature Cell Biology volume 16, pages 504506 (2014) | Download Citation

Despite the widespread occurrence of aneuploidy in cancer cells, the molecular causes for chromosomal instability are not well established. Cyclin B2 is now shown to control a pathway — involving the centrosomal kinases aurora A and Plk1 and the tumour suppressor p53 — the alteration of which causes defective centrosome separation, aneuploidy and tumour development.

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Author information

Affiliations

  1. Guillermo de Cárcer and Marcos Malumbres are in the Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain

    • Guillermo de Cárcer
    •  & Marcos Malumbres

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Marcos Malumbres.

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DOI

https://doi.org/10.1038/ncb2978

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