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Motivating endosome motility

Nature Cell Biology volume 1, pages E145–E147 (1999)Cite this article

Abstract

The GTPase Rab5 regulates the fusion of early endosomes. Activated Rab5 interacts with phosphatidylinositol-3-OH kinase and with the endosome-tethering protein EEA1. These interactions lead to enhanced motility of endosomes along microtubules.

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Figure 1: Model for Rab5-stimulated endosome movement along microtubules5.

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Authors and Affiliations

  1. Department of Biochemistry Stanford University School of Medicine, Stanford, 94305-5307, California , USA

    Suzanne R. Pfeffer

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  1. Suzanne R. Pfeffer
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Correspondence to Suzanne R. Pfeffer.

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Pfeffer, S. Motivating endosome motility. Nat Cell Biol 1, E145–E147 (1999). https://doi.org/10.1038/14097

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