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Pores galore for the Golgi

Strict control of cisternal pH in the Golgi is required for posttranslational modification and trafficking of proteins and lipids. A chloride channel to neutralize the charge of the proton pump and to keep the Golgi membrane potential near zero has finally been discovered.

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Figure 1: pH regulation at the Golgi.
Figure 2: Schematic representation of hypothetical models to explain subconductance states of GPHR trimers.

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Caldwell, J., Howell, K. Pores galore for the Golgi. Nat Cell Biol 10, 1125–1126 (2008). https://doi.org/10.1038/ncb1008-1125

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