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Refocusing on BRCA1

Nature Cell Biology volume 6, pages 916–917 (2004)Cite this article

A panoply of functions have been proposed for the BRCA1 cancer susceptibility protein, particularly in the response to DNA damage and in transcriptional regulation. This complexity is now exacerbated by the discovery of a distinct splice variant of BRCA1, BRCA1/IRIS, with a previously uncharacterized function in DNA replication. This has implications for understanding tumorigenesis in BRCA1 mutation carriers.

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Figure 1: Structure and function of two products of the BRCA1 gene1.

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  1. The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK

    Alan Ashworth

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  1. Alan Ashworth
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Ashworth, A. Refocusing on BRCA1. Nat Cell Biol 6, 916–917 (2004). https://doi.org/10.1038/ncb1004-916

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