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The mesh hypothesis of Golgi dynamics


The GTP-binding protein ARF induces the recruitment to the Golgi membrane of kinases that catalyse the synthesis of the lipid phosphatidylinositol-4,5-bisphosphate. This lipid acts as a binding site for certain actin-binding proteins, which may change the Golgi membrane skeleton to a form that allows membrane traffic.

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Figure 1: ARF recruits phosphatidylinositol (PtdIns)-4-OH kinase-β (PI4Kβ) and a PtdIns-4-phosphate-5-OH kinase (PtdIns(4)P-5-OH kinase) to the Golgi membrane1.
Figure 2: The mesh hypothesis of Golgi membrane dynamics.


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Lorra, C., Huttner, W. The mesh hypothesis of Golgi dynamics. Nat Cell Biol 1, E113–E115 (1999).

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