Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The mesh hypothesis of Golgi dynamics

Nature Cell Biology volume 1, pages E113–E115 (1999)Cite this article

Abstract

The GTP-binding protein ARF induces the recruitment to the Golgi membrane of kinases that catalyse the synthesis of the lipid phosphatidylinositol-4,5-bisphosphate. This lipid acts as a binding site for certain actin-binding proteins, which may change the Golgi membrane skeleton to a form that allows membrane traffic.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: ARF recruits phosphatidylinositol (PtdIns)-4-OH kinase-β (PI4Kβ) and a PtdIns-4-phosphate-5-OH kinase (PtdIns(4)P-5-OH kinase) to the Golgi membrane1.
Figure 2: The mesh hypothesis of Golgi membrane dynamics.

References

  1. Godi, A. et al. Nature Cell Biol. 1, 280–287 (1999).

    Article  CAS  Google Scholar 

  2. Rothman, J. E. Nature 372, 55–63 (1994).

    Article  CAS  Google Scholar 

  3. Schekman, R. & Orci, L. Science 271, 1526–1533 (1996).

    Article  CAS  Google Scholar 

  4. Martin, T. F. J. Curr. Opin. Neurobiol. 7, 331–338 (1997).

    Article  CAS  Google Scholar 

  5. De Camilli, P., Emr, S. D., McPherson, P. S. & Novick, P. Science 271, 1533–1539 (1996).

    Article  CAS  Google Scholar 

  6. Ohashi, M. et al. Nature 377, 544–547 (1995).

    Article  CAS  Google Scholar 

  7. Brown, H. A., Gutowski, S., Moomaw, C. R., Slaughter, C. & Sternweis, P. C. Cell 75, 1137–1144 (1993).

    Article  CAS  Google Scholar 

  8. Tüscher, O., Lorra, C., Bouma, B., Wirtz, K. W. A. & Huttner, W. B. FEBS Lett. 419, 271–275 (1997).

    Article  Google Scholar 

  9. Godi, A. et al. Proc. Natl Acad. Sci. USA 95, 8607–8612 (1998).

    Article  CAS  Google Scholar 

  10. Beck, K. A. & Nelson, W. J. Biochim. Biophys. Acta 1404, 153–160 (1998).

    Article  CAS  Google Scholar 

  11. De Matteis, M. A. & Morrow, J. S. Curr. Opin. Cell Biol. 10, 542–549 (1998).

    Article  CAS  Google Scholar 

  12. Holleran, E. A. & Holzbaur, E. L. F. Trends Cell Biol. 8, 26–29 (1998).

    Article  CAS  Google Scholar 

  13. Stankewich, M. C. et al. Proc. Natl Acad. Sci. USA 95, 14158–14163 (1998).

    Article  CAS  Google Scholar 

  14. Kreis, T. & Vale, R. Guidebook to the Cytoskeletal and Motor Proteins (Sambrook & Tooze, Oxford Univ. Press, Oxford, 1999).

    Google Scholar 

  15. Müsch, A., Cohen, D. & Rodriguez-Boulan, E. J. Cell Biol. 138, 291–306 (1997).

    Article  Google Scholar 

  16. Ikonen, E. et al. J. Cell Sci. 110, 2155–2164 (1997).

    CAS  PubMed  Google Scholar 

  17. Hendricks, K. B., Wang, B. Q., Schnieders, E. A. & Thorner, J. Nature Cell Biol. 1, 234–241 (1999).

    Article  CAS  Google Scholar 

  18. Pongs, O. et al. Neuron 11, 15–28 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, Heidelberg, D-69120, Germany

    Christoph Lorra & Wieland B. Huttner

  2. Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, D-01307, Germany

    Christoph Lorra & Wieland B. Huttner

Authors
  1. Christoph Lorra
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wieland B. Huttner
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lorra, C., Huttner, W. The mesh hypothesis of Golgi dynamics. Nat Cell Biol 1, E113–E115 (1999). https://doi.org/10.1038/12939

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/12939

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing