Historical Perspective | Published:

The lysosome turns fifty

Nature Cell Biology volume 7, pages 847849 (2005) | Download Citation

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Abstract

In the course of an investigation aimed at characterizing hepatic glucose 6-phosphatase, the unrelated acid phosphatase of rat liver was serendipitously observed to be latent and particle-bound in freshly prepared homogenates. Experiments designed to elucidate this intriguing finding led, 50 years ago, to the discovery of lysosomes. This could not have happened if strict adherence to a previously set programme had been mandatory.

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Author information

Affiliations

  1. Christian de Duve is Emeritus Professor at the Catholic University of Louvain, Belgium, and at the Rockefeller University, New York. deduve@icp.ucl.ac.be

    • Christian de Duve

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DOI

https://doi.org/10.1038/ncb0905-847

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