Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Viral entry: a detour through multivesicular bodies

Nature Cell Biology volume 7, pages 641–642 (2005)Cite this article

Many viruses and toxins enter the cytoplasm of cells by crossing endosomal membranes. New evidence now suggests that if entry occurs through multivesicular bodies, then they are first delivered into intraluminal vesicles before their final transfer into the cytoplasm via the 'back-fusion' of these vesicles.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Membrane dynamics at the MVB.

References

  1. Kleijmeer, M. et al. J. Cell Biol. 155, 53–63 (2001).

    Article  CAS  Google Scholar 

  2. Chow, A., Toomre, D., Garrett, W. & Mellman, I. Nature 418, 988–994 (2002).

    Article  CAS  Google Scholar 

  3. Murk, J.L. et al. Proc. Natl Acad. Sci. USA 100, 13332–13337 (2003).

    Article  CAS  Google Scholar 

  4. Le Blanc, I. Nature Cell Biol. 7, 653–664 (2005).

    Article  CAS  Google Scholar 

  5. Matsuo, H. et al. Science 303, 531–534 (2004).

    Article  CAS  Google Scholar 

  6. Abrami, L., Lindsay, M., Parton, R.G., Leppla, S.H. & van der Goot, F.G. J. Cell Biol. 166, 645–651 (2004).

    Article  CAS  Google Scholar 

  7. Thery, C., Zitvogel, L. & Amigorena, S. Nature Rev. Immunol. 2, 569–579 (2002).

    Article  CAS  Google Scholar 

  8. Miller, B.J., Georges-Labouesse, E., Primakoff, P. & Myles, D.G. J. Cell Biol. 149, 1289–1296 (2000).

    Article  CAS  Google Scholar 

  9. Trombetta, E.S., Ebersold, M., Garrett, W., Pypaert, M. & Mellman, I. Science 299, 1400–1403 (2003).

    Article  CAS  Google Scholar 

  10. Chandran, K., Sullivan, N.J., Felbor, U., Whelan, S.P. & Cunningham, J.M. Science 308, 1643–1645 (2005).

    Article  CAS  Google Scholar 

  11. Khor, R., McElroy, L.J. & Whittaker, G.R. Traffic 4, 857–868 (2003).

    Article  CAS  Google Scholar 

  12. Sieczkarski, S.B. & Whittaker, G.R. Traffic 4, 333–343 (2003).

    Article  CAS  Google Scholar 

  13. Lakadamyali, M., Rust, M.J., Babcock, H.P. & Zhuang, X. Proc. Natl Acad. Sci. USA 100, 9280–9285 (2003).

    Article  CAS  Google Scholar 

  14. Morita, E. & Sundquist, W.I. Annu. Rev. Cell Dev. Biol. 20, 395–425 (2004).

    Article  CAS  Google Scholar 

  15. Wagner, H. Trends Immunol. 25, 381–386 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, 06536, CT, USA

    Pradeep Uchil & Walther Mothes

Authors
  1. Pradeep Uchil
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Walther Mothes
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Uchil, P., Mothes, W. Viral entry: a detour through multivesicular bodies. Nat Cell Biol 7, 641–642 (2005). https://doi.org/10.1038/ncb0705-641

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0705-641

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing