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The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly

Nature Cell Biology volume 4, pages E177–E184 (2002)Cite this article

Abstract

The small GTPase Ran is a key regulator of nucleocytoplasmic transport during interphase. The asymmetric distribution of the GTP-bound form of Ran across the nuclear envelope — that is, large quantities in the nucleus compared with small quantities in the cytoplasm — determines the directionality of many nuclear transport processes. Recent findings that Ran also functions in spindle formation and nuclear envelope assembly during mitosis suggest that Ran has a general role in chromatin-centred processes. Ran functions in these events as a signal for chromosome position.

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Figure 1: Ran can affect multiple spindle targets.
Figure 2: Steps of nuclear envelope (NE) formation in vitro.
Figure 3: Model of nuclear envelope (NE) formation.
Figure 4: RanGTP as a marker of chromosome position.

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Acknowledgements

We thank W. Antonin, P. Askjaer, R. Carazo-Salas, J. Ellenberg, V. Hachet and T. Walther for critical reading and helpful comments.

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  1. European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, 69117, Germany

    Martin Hetzer, Oliver J. Gruss & Iain W. Mattaj

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Hetzer, M., Gruss, O. & Mattaj, I. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nat Cell Biol 4, E177–E184 (2002). https://doi.org/10.1038/ncb0702-e177

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