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SUMO amplifies TGF-β signalling

Nature Cell Biology volume 10, pages 635–637 (2008)Cite this article

Transforming growth factor-β (TGF-β) stimulates phosphorylation of TGF-β type I receptor. This receptor is now shown to be sumoylated, leading to enhanced activation and modulation of the downstream Smad signalling pathway.

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Figure 1: Proposed model of R-Smads phosphorylation by TβRI.

References

  1. Johnsson, E. S. Annu. Rev. Biochem. 74, 355–382 (2004).

    Article  Google Scholar 

  2. Kang, J. S., Saunier, E. F., Akhurst, R. J. & Derynck, R. Nature Cell Biol. 10, 654–664 (2008).

    Article  CAS  Google Scholar 

  3. Shi, Y. & Massagué, J. Cell 113, 685–700 (2003).

    Google Scholar 

  4. Kavsak, O. et al. Mol. Cell 6, 1365–1375 (2000).

    Article  CAS  Google Scholar 

  5. Ebisawa, T. et al. J. Biol. Chem. 276, 12477–12480 (2001).

    Article  CAS  Google Scholar 

  6. Lin, X., Chen, Y.-G. & Feng, X.-F. in The TGF-β Family 287–332 (Cold Spring Harbor Laboratory Press, NY, 2008).

    Google Scholar 

  7. Feng, X.-H. & Derynck, R. Annu. Rev. Cell Dev. Biol. 21, 659–93 (2005).

    Article  CAS  Google Scholar 

  8. Shimizu, A. et al. Genes Cells 3, 125–134 (1998).

    Article  CAS  Google Scholar 

  9. Shi, W. et al. J. Cell Biol. 164, 291–300 (2004).

    Article  CAS  Google Scholar 

  10. Zhang, Y. E. in The TGF-β Family 419–438 (Cold Spring Harbor Laboratory Press, NY, 2008).

    Google Scholar 

  11. Chen, T., Carter, D., Garrigue-Antar, L. & Reiss, M. Cancer Res. 58, 4805–4810 (1998).

    CAS  PubMed  Google Scholar 

  12. Chen, T. et al. Int. J. Cancer 93, 653–661 (2001).

    Article  CAS  Google Scholar 

  13. Roberts, A. B. & Wakefield, L. M. Proc. Natl Acad. Sci. USA 100, 8621–8623 (2003).

    Article  CAS  Google Scholar 

  14. Martin, S., Nishimune, A., Mellor, J. R. & Henley, J. M. Nature 447, 321–325 (2007).

    Article  CAS  Google Scholar 

  15. Yingling, J. M., Blanchard, K. L., & Sawyer, J. S. Nature Rev. Drug. Discov. 3, 1011–1022 (2004).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Yuto Kamiya and Keiji Miyazawa are in the Department of Molecular Pathology, Kohei Miyazono, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. miyazono-ind@umin.ac.jp mm66211@mail.ecc.u-tokyo.ac.jp keiji-miyazawa@umin.ac.jp,

    Kohei Miyazono, Yuto Kamiya & Keiji Miyazawa

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  1. Kohei Miyazono
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  3. Keiji Miyazawa
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Miyazono, K., Kamiya, Y. & Miyazawa, K. SUMO amplifies TGF-β signalling. Nat Cell Biol 10, 635–637 (2008). https://doi.org/10.1038/ncb0608-635

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