Correct timing of developmental events is crucial for generating a normal organism. During oogenesis in Drosophila melanogaster, migration of border cells occurs in a defined temporal window and requires Jak/Stat and steroid hormone signalling. The initiation of border-cell migration is now shown to be timed by Jak/Stat-mediated downregulation of the BTB domain transcriptional regulator Abrupt, which acts as a negative regulator of steroid hormone signalling.
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Godt, D., Tepass, U. Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration. Nat Cell Biol 11, 536–538 (2009). https://doi.org/10.1038/ncb0509-536
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DOI: https://doi.org/10.1038/ncb0509-536