Expression of the cell cycle inhibitor p15INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.
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Amati, B. Integrating Myc and TGF-β signalling in cell-cycle control. Nat Cell Biol 3, E112–E113 (2001). https://doi.org/10.1038/35074634
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DOI: https://doi.org/10.1038/35074634
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