Delivery of transmembrane proteins to the lumen of the lysosome is mediated by their ubiquitination, and subsequent recognition and sorting at the endosome. A new group of ubiquitin-binding proteins has now been identified that seem to function in the delivery of ubiquitinated cargo both from the cell surface and the trans-Golgi network (TGN) to the lysosome.
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Babst, M. GGAing ubiquitin to the endosome. Nat Cell Biol 6, 175–177 (2004). https://doi.org/10.1038/ncb0304-175
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DOI: https://doi.org/10.1038/ncb0304-175
