Early endosomes are the first sorting station from which endocytosed materials are targeted to various intracellular destinations. Recent work has identified the FYVE-domain protein rabenosyn-5 as a bifunctional effector of the GTPases rab5 and rab4, physically connecting entry and recycling sites on early endosomes.
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References
de Renzis, S., Sönnichsen, B. & Zerial, M. Nature Cell Biol. 4, 124–133 (2002).
Lin, S. X., Grant, B., Hirsch, D. & Maxfield, F. Nature Cell Biol. 3, 567–572 (2001).
Patki, V., Lawe, D. C., Corvera, S., Virbasius, J. V. & Chawla, A. Nature 394, 433–434 (1998).
Simonsen, A. & Stenmark, H. PX domains: Nature Cell Biol. 3, E179–E182 (2001).
Gillooly, D. J. et al. EMBO J. 19, 4577–4588 (2000).
Fernandez-Borja, M. et al. Curr. Biol. 9, 55–58 (1999).
Gruenberg, J. Nature Rev. Mol. Cell Biol. 2, 721–730 (2001).
Bucci, C. et al. Cell 70, 715–728 (1992).
de Wit, H. et al. Mol. Biol. Cell 12, 3703–3715 (2001).
Ullrich, O., Reinsch, O., Urbe, S., Zerial, M. & Parton, R. J. Cell Biol. 135, 913–924 (1996).
Sönnichsen, B., De Renzis, S., Nielsen, E., Rietdorf, J. & Zerial, M. J. Cell Biol. 149, 901–913 (2000).
Nielsen, E. et al. J. Cell Biol. 151, 601–612 (2000).
Bryant, N. J. & James, D. E. EMBO J. 13, 3380–3388 (2001).
Gournier, H., Stenmark, H., Rybin, V., Lippe, R. & Zerial, M. EMBO J. 17, 1930–1940 (1998).
Page, L., Sowerby, P. J., Lui, W. W. Y. & Robinson, M. S. J. Cell Biol. 146, 993–1004 (1999).
van der Sluijs, P. et al. Cell 70, 729–740 (1992).
Valsdottir, R. et al. FEBS Lett. 508, 201–209 (2001).
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Deneka, M., van der Sluijs, P. 'Rab'ing up endosomal membrane transport. Nat Cell Biol 4, E33–E35 (2002). https://doi.org/10.1038/ncb0202-e33
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DOI: https://doi.org/10.1038/ncb0202-e33
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