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Mitosis: a history of division

Abstract

Mitosis has been studied since the early 1880s, to the extent that we now have a detailed, but still incomplete, description of spindle dynamics and mechanics, a sense of potential mechanochemical and regulatory mechanisms at a molecular level, and a long list of mitotic proteins. Here we present a personal view of how far we have come, and where we need to go to fully understand the mechanisms involved in mitosis.

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Figure 1: Old and new views of mitotic chromosomes.
Figure 2: Evolution of ideas for spindle organization and force generation.
Figure 3: Evolution of microtubule-marking technology.
Figure 4: Motor proteins are important in spindle assembly and function.
Figure 5: Mitotic arrest and the spindle-assembly checkpoint.

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Nature Cell Biology gratefully acknowledges all the publishers who provided images for this work.

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Figure S1a

Evidence of highly dynamic spindle microtubules (PDF 44 kb)

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Mitchison, T., Salmon, E. Mitosis: a history of division. Nat Cell Biol 3, E17–E21 (2001). https://doi.org/10.1038/35050656

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