Electrospray ionization mass spectrometry (ESI-MS) precisely measures molecular masses without disrupting noncovalent protein interactions, and so provides a powerful tool for studying protein complexes. In this issue ( p.1214), Naylor and colleagues take the method a step further, using it to analyze the effect of ligands on heterodimerization of full-length vitamin D and retinoid X receptors, and their binding to specific DNA sequences.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DeWitt, N. Mass analysis of receptor–DNA complexes. Nat Biotechnol 17, 1150 (1999). https://doi.org/10.1038/70675
Issue Date:
DOI: https://doi.org/10.1038/70675