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Sense versus nonsense in DNA diagnostics

Nature Biotechnology volume 19, pages 413–414 (2001)Cite this article

An approach for detecting chain-termination mutations could prove tremendously useful in developing diagnostics for human disease.

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Figure 1: A model for the NMD pathway4.

© Bob Crimi

References

  1. Leeds, P. et al. Genes Dev. 5, 2303–2314 (1991).

    Article  CAS  Google Scholar 

  2. Pulak, R. & Anderson, P. Genes Dev. 7, 1885–1897 (1993).

    Article  CAS  Google Scholar 

  3. Noensie, E.N. & Dietz, H.C. Nat. Biotechnol. 19, 434–439 (2001).

    Article  CAS  Google Scholar 

  4. Culbertson, M.R. Trends Genet. 15, 74–80 (1999).

    Article  CAS  Google Scholar 

  5. Shirley, R.L. et al. J. Cell Sci. 14, 3129–3143 (1998).

    Google Scholar 

  6. Lykke-Andersen, J., Shu, M.D. & Steitz J.A. Cell 103, 1121–1131 (2000).

    Article  CAS  Google Scholar 

  7. Leeds, P. et al. Mol. Cell Biol. 12, 2165–2177 (1992).

    Article  CAS  Google Scholar 

  8. Sun, X. et al. Proc. Natl. Acad. Sci. USA 95, 10009–10014 (1998).

    Article  CAS  Google Scholar 

  9. Lelivelt, M.J. & Culbertson, M.R. Mol. Cell. Biol. 19, 6710–6719 (1999).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratories of Genetics and Molecular Biology, 1525 Linden Drive

    Michael R. Culbertson

  2. University of Wisconsin, Madison, 53706, WI

    Michael R. Culbertson

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  1. Michael R. Culbertson
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Culbertson, M. Sense versus nonsense in DNA diagnostics. Nat Biotechnol 19, 413–414 (2001). https://doi.org/10.1038/88061

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