Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cancer development

Origins in the oesophagus

The cellular origins of a precancerous condition called Barrett's oesophagus have been unclear. Tracking and analysis of epithelial cells at the affected site could shed light on the problem. See Letter p.529

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Dissection of epithelial-cell types in the oesophagus.


  1. 1.

    See all news & views


  1. 1

    Jiang, M. et al. Nature 550, 529–533 (2017).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Giroux, V. & Rustgi, A. K. Nature Rev. Cancer 17, 594–604 (2017).

    CAS  Article  Google Scholar 

  3. 3

    McDonald, S. A., Lavery, D., Wright, N. A. & Jansen, M. Nature Rev. Gastroenterol. Hepatol. 12, 50–60 (2015).

    Article  Google Scholar 

  4. 4

    Spechler, S. J. & Souza, R. F. N. Engl. J. Med. 371, 836–845 (2014).

    CAS  Article  Google Scholar 

  5. 5

    Glickman, J. N., Chen, Y. Y., Wang, H. H., Antonioli, D. A. & Odze, R. D. Am. J. Surg. Pathol. 25, 569–578 (2001).

    CAS  Article  Google Scholar 

  6. 6

    Cabibi, D. et al. Med. Sci. Monit. 15, CR203–CR210 (2009).

    CAS  Article  Google Scholar 

  7. 7

    Coleman, H. G., Xie, S.-H. & Lagergren, J. Gastroenterology (2017).

  8. 8

    Phillips, R. W., Frierson, H. F. & Moskaluk, C. A. Am. J. Surg. Pathol. 27, 1442–1447 (2003).

    Article  Google Scholar 

  9. 9

    Blokzijl, F. et al. Nature 538, 260–264 (2016).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Ross-Innes, C. S. et al. Nature Genet. 47, 1038–1046 (2015).

    CAS  Article  Google Scholar 

  11. 11

    Hamilton, S. R. & Yardley, J. H. Gastroenterology 72, 669–675 (1977).

    CAS  PubMed  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Rebecca C. Fitzgerald.

Related links

Related links

Related links in Nature Research

Cancer genomics: Spot the difference

Biological techniques: Stomach growth in a dish

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zhuang, L., Fitzgerald, R. Origins in the oesophagus. Nature 550, 463–464 (2017).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing