Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell signalling

Red alert about lipid's role in skin cancer

Some versions of the MC1R protein are associated with red hair and an increased risk of developing a skin cancer called melanoma. It emerges that a lipid that binds MC1R might provide a target to reduce this risk. See Letter p.399

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Lipid link to skin cancer.

Notes

  1. See all news & views

References

  1. Chen, S. et al. Nature 549, 399–403 (2017).

    Article  CAS  ADS  Google Scholar 

  2. Valverde, P., Healy, E., Jackson, I., Rees, J. L. & Thody, A. J. Nature Genet. 11, 328–330 (1995).

    Article  CAS  Google Scholar 

  3. Robbins, L. S. et al. Cell 72, 827–834 (1993).

    Article  CAS  Google Scholar 

  4. Newton, J. M. et al. Mamm. Genome 11, 24–30 (2000).

    Article  CAS  Google Scholar 

  5. Sturm, R. A. et al. Ann. NY Acad. Sci. 994, 348–358 (2003).

    Article  CAS  ADS  Google Scholar 

  6. Saleem, A. N. et al. PLoS Genet. 6, e1000985 (2010).

    Article  Google Scholar 

  7. Perez, C. J. et al. J. Invest. Dermatol. 135, 3133–3143 (2015).

    Article  CAS  Google Scholar 

  8. Dankort, D. et al. Nature Genet. 41, 544–552 (2009).

    Article  CAS  Google Scholar 

  9. Cui, R. et al. Cell 128, 853–864 (2007).

    Article  CAS  Google Scholar 

  10. Hauser, J. E. et al. Pigment Cell Res. 19, 303–314 (2006).

    Article  CAS  Google Scholar 

  11. Mitra, D. et al. Nature 491, 449–453 (2012).

    Article  CAS  ADS  Google Scholar 

  12. Wendt, J. et al. JAMA Dermatol. 152, 776–782 (2016).

    Article  Google Scholar 

  13. D'Orazio, J. A. et al. Nature 443, 340–344 (2006).

    Article  CAS  ADS  Google Scholar 

  14. Beaumont, K. A. et al. Hum. Mol. Genet. 14, 2145–2154 (2005).

    Article  CAS  Google Scholar 

  15. Tagliabue, E. et al. Br. J. Cancer 113, 354–363 (2015).

    Article  CAS  Google Scholar 

  16. Jeon, S., Kim, N.-H., Koo, B.-S., Kim, J.-Y. & Lee, A. Y. Exp. Mol. Med. 41, 517–524 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Ian J. Jackson or E. Elizabeth Patton.

Related links

Related links

Related links in Nature Research

Cancer: Complexion matters

Cell biology: Healthy skin rejects cancer

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Jackson, I., Patton, E. Red alert about lipid's role in skin cancer. Nature 549, 337–339 (2017). https://doi.org/10.1038/nature23550

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature23550

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer