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Biochemistry

A toxin that fuels metabolism

Formaldehyde, a DNA-damaging agent formed in cells, has now been shown to support metabolic processes that involve molecular units containing a single carbon atom — linking metabolism to a DNA-protection mechanism. See Article p.549

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Figure 1: Formaldehyde fuels one-carbon metabolism.

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Correspondence to Jason W. Locasale.

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Liu, X., Locasale, J. A toxin that fuels metabolism. Nature 548, 533–534 (2017). https://doi.org/10.1038/nature23541

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