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Gut sensor halts viral attack

Intestinal infection with rotavirus is a major cause of diarrhoea in infants, and can be fatal. The identification of immune sensor proteins that detect and restrict this viral infection now illuminates the body's defence system. See Letter p.667

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Figure 1: Rotavirus detection in intestinal cells.


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  1. Tate, J. E. et al. Clin. Infect. Dis. 62 (Suppl. 2), S96–S105 (2016).

    Article  Google Scholar 

  2. Zhu, S. et al. Nature 546, 667–670 (2017).

    ADS  CAS  Article  Google Scholar 

  3. Lamkanfi, M. & Dixit, V. M. Cell 157, 1013–1022 (2014).

    CAS  Article  Google Scholar 

  4. Saavedra, P. H., Demon, D., Van Gorp, H. & Lamkanfi, M. Semin. Immunopathol. 37, 313–322 (2015).

    CAS  Article  Google Scholar 

  5. Kayagaki, N. et al. Nature 526, 666–671 (2015).

    ADS  CAS  Article  Google Scholar 

  6. Shi, J. et al. Nature 526, 660–665 (2015).

    ADS  CAS  Article  Google Scholar 

  7. Aglietti, R. A. et al. Proc. Natl Acad. Sci. USA 113, 7858–7863 (2016).

    CAS  Article  Google Scholar 

  8. Liu, X. et al. Nature 535, 153–158 (2016).

    ADS  CAS  Article  Google Scholar 

  9. Sborgi, L. et al. EMBO J. 35, 1766–1778 (2016).

    CAS  Article  Google Scholar 

  10. Van Gorp, H., Kuchmiy, A., Van Hauwermeiren, F. & Lamkanfi, M. FEBS J. 281, 4568–4582 (2014).

    CAS  Article  Google Scholar 

  11. Aktaş, T. et al. Nature 544, 115–119 (2017).

    ADS  Article  Google Scholar 

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Correspondence to Mohamed Lamkanfi.

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Saavedra, P., Lamkanfi, M. Gut sensor halts viral attack. Nature 546, 606–608 (2017).

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