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Immunology

Gut sensor halts viral attack

Nature volume 546, pages 606–608 (2017)Cite this article

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Intestinal infection with rotavirus is a major cause of diarrhoea in infants, and can be fatal. The identification of immune sensor proteins that detect and restrict this viral infection now illuminates the body's defence system. See Letter p.667

Intestinal cells can be infected by a type of virus known as a rotavirus, which is one of the leading causes of severe diarrhoea in infants and young children worldwide. Although effective rotavirus vaccines have been available since 2006, routine vaccination has been adopted in only a few developing countries, and it is estimated that the virus causes more than 200,000 childhood deaths annually1. There is only limited understanding of how intestinal cells sense rotavirus infection and mount an antiviral response. Now, on page 667, Zhu et al.2 identify host proteins that are key components of this response.

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Figure 1: Rotavirus detection in intestinal cells.

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Authors and Affiliations

  1. Center for Inflammation Research, VIB, Ghent, B-9052, Belgium

    Pedro H. V. Saavedra & Mohamed Lamkanfi

  2. Department of Internal Medicine, Ghent University,

    Pedro H. V. Saavedra & Mohamed Lamkanfi

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  1. Pedro H. V. Saavedra
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  2. Mohamed Lamkanfi
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Correspondence to Mohamed Lamkanfi.

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Saavedra, P., Lamkanfi, M. Gut sensor halts viral attack. Nature 546, 606–608 (2017). https://doi.org/10.1038/nature23090

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