Lupus is an autoimmune disease that can cause brain dysfunction. Studies in mouse models of lupus find that interferon proteins can cause the brain's immune cells to trim the synaptic connections between neurons. See Letter p.539
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UpdateThis News & Views article commented on a paper, entitled 'Microglia-dependent synapse loss in type I interferon-mediated lupus' (A. R. Bialas et al. Nature 546, 539–543; 2017), that has now been retracted.
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McGlasson, S., Hunt, D. Synapses pruned in lupus. Nature 546, 482–483 (2017). https://doi.org/10.1038/nature23087