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Structural biology

Growth factor rattled out of its cage

The growth factor TGF-ß1 is located inside a protein cage, and is thought to be released by force applied through integrin proteins. A structure of TGF-ß1 in complex with integrin αVß6 sheds light on the uncaging process. See Article p.55

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Figure 1: Force-induced activation of TGF-β1.

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Correspondence to Taekjip Ha.

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Ha, T. Growth factor rattled out of its cage. Nature 542, 40–41 (2017). https://doi.org/10.1038/nature21119

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