Identification of a previously uncharacterized genetic disease highlights DNA repair as a shared mechanism in neurodegenerative disorders, and suggests potential therapeutic approaches to tackling them. See Letter p.87
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Rad1 attenuates DNA double-strand breaks and cell cycle arrest in type II alveolar epithelial cells of rats with bronchopulmonary dysplasia
Molecular Medicine Open Access 24 May 2023
-
Cross-sectional analysis of plasma and CSF metabolomic markers in Huntington’s disease for participants of varying functional disability: a pilot study
Scientific Reports Open Access 24 November 2020
-
Somatic mutations in the DNA repairome in prostate cancers in African Americans and Caucasians
Oncogene Open Access 16 April 2020
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Balchin, D., Hayer-Hartl, M. & Hartl, F. U. Science 353, aac4354 (2016).
Hoch, N. C. et al. Nature 541, 87–91 (2016).
Jiang, B., Glover, J. N. M. & Weinfeld, M. Mech. Ageing Dev. http://dx.doi.org/10.1016/j.mad.2016.07.009 (2016).
Ross, C. A. et al. Nature Rev. Neurol. 10, 204–216 (2014).
Genetic Modifiers of Huntington's Disease (GeM-HD) Consortium. Cell 162, 516–526 (2015).
Bettencourt, C. et al. Ann. Neurol. 79, 983–990 (2016).
Fujita, K. et al. Nature Commun. 4, 1816 (2013).
Lu, X. H. et al. Sci. Transl. Med. 6, 268ra178 (2014).
Maiuri, T. et al. Hum. Mol. Genet. (in the press).
Lovell, M. A., Gabbita, S. P. & Markesbery, W. R. J. Neurochem. 72, 771–776 (1999).
Markesbery, W. R. & Lovell, M. A. Antioxid. Redox Signal. 8, 2039–2045 (2006).
Author information
Authors and Affiliations
Corresponding authors
Related links
Rights and permissions
About this article
Cite this article
Ross, C., Truant, R. A unifying mechanism in neurodegeneration. Nature 541, 34–35 (2017). https://doi.org/10.1038/nature21107
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature21107
This article is cited by
-
PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation
The EMBO Journal (2024)
-
Rad1 attenuates DNA double-strand breaks and cell cycle arrest in type II alveolar epithelial cells of rats with bronchopulmonary dysplasia
Molecular Medicine (2023)
-
DNA Double-Strand Break Accumulation in Alzheimer’s Disease: Evidence from Experimental Models and Postmortem Human Brains
Molecular Neurobiology (2021)
-
Somatic mutations in the DNA repairome in prostate cancers in African Americans and Caucasians
Oncogene (2020)
-
Cross-sectional analysis of plasma and CSF metabolomic markers in Huntington’s disease for participants of varying functional disability: a pilot study
Scientific Reports (2020)