Spliceosome complexes remove non-coding sequences from RNA transcripts in two steps. A structure of a spliceosome after the first step reveals active-site interactions and evolutionary constraints on these non-coding regions. See Article p.197
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Kosmyna, B., Query, C. Catalytic spliceosome captured. Nature 537, 175–176 (2016). https://doi.org/10.1038/nature19422
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DOI: https://doi.org/10.1038/nature19422
