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Immunotherapy

Cancer vaccine triggers antiviral-type defences

An immunotherapy approach targets nanoparticles to dendritic cells of the immune system, leading to an antitumour immune response with antiviral-like features. Initial clinical tests of this approach show promise. See Letter p.396

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Figure 1: An antitumour nanoparticle vaccine.

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References

  1. 1

    Kranz, L. M. et al. Nature 534, 396–401 (2016).

    Article  ADS  Google Scholar 

  2. 2

    Joyce, J. A. & Fearon, D. T. Science 348, 74–80 (2015).

    CAS  Article  ADS  Google Scholar 

  3. 3

    Palucka, K. & Banchereau, J. Nature Rev. Cancer 12, 265–277 (2012).

    CAS  Article  Google Scholar 

  4. 4

    Tel, J. et al. Cancer Res. 73, 1063–1075 (2013).

    CAS  Article  Google Scholar 

  5. 5

    Tacken, P. J., de Vries, I. J., Torensma, R. & Figdor, C. G. Nature Rev. Immunol. 7, 790–802 (2007).

    CAS  Article  Google Scholar 

  6. 6

    Bonifaz, L. C. et al. J. Exp. Med. 196, 1627–1638 (2002).

    CAS  Article  Google Scholar 

  7. 7

    Bonifaz, L. C. et al. J. Exp. Med. 199, 815–824 (2004).

    CAS  Article  Google Scholar 

  8. 8

    Tacken, P. J. et al. Blood 106, 1278–1285 (2005).

    CAS  Article  Google Scholar 

  9. 9

    Cruz, L. J. et al. J. Control. Release 144, 118–126 (2010).

    CAS  Article  Google Scholar 

  10. 10

    https://clinicaltrials.gov/ct2/results?term=dec-205&Search=Search

  11. 11

    Kuhn, A. N. et al. Gene Ther. 17, 961–971 (2010).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Jolanda De Vries or Carl Figdor.

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De Vries, J., Figdor, C. Cancer vaccine triggers antiviral-type defences. Nature 534, 329–331 (2016). https://doi.org/10.1038/nature18443

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