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Immunology

Organelle stress triggers inflammation

The intracellular NOD1 and NOD2 receptors have been found to activate innate inflammation when a condition known as endoplasmic reticulum stress is induced by bacterial infection. See Letter p.394

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Figure 1: NOD proteins respond to infection through distinct pathways.

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Correspondence to Bennett H. Penn or Jeffery S. Cox.

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Penn, B., Cox, J. Organelle stress triggers inflammation. Nature 532, 321–322 (2016). https://doi.org/10.1038/nature17882

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