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Cell biology

Calcium contradictions in cilia

Organelles called primary cilia that protrude from cells have been thought to sense the surrounding environment through calcium-channel proteins that respond to force. Two scientists discuss the implications for developmental biology and kidney disease of a study that challenges this hypothesis. See Letter p.656

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Figure 1: The mechanosensation hypothesis.

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Correspondence to Dominic P. Norris or Peter K. Jackson.

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Norris, D., Jackson, P. Calcium contradictions in cilia. Nature 531, 582–583 (2016). https://doi.org/10.1038/nature17313

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