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Respiratory disorders

Ironing out smoking-related airway disease

Lack of the protein IRP2 in mice prevents organelles called mitochondria from accumulating toxic levels of iron in response to smoke exposure. This discovery links environmental and genetic risk factors for a chronic lung disease.

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Figure 1: Regulation of mucociliary clearance in chronic obstructive pulmonary disease (COPD).


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Correspondence to Thomas J. Mariani.

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Mariani, T. Ironing out smoking-related airway disease. Nature 531, 586–587 (2016).

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