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Cell biology

Lipid code for membrane recycling

Nature volume 529, pages 292–293 (2016)Cite this article

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The sequential action of enzymes has been shown to modify members of a class of membrane lipid called phosphoinositides to direct integral membrane proteins for recycling. See Letter p.408

The ability of cells to take up nutrients or receive signals from their neighbours depends on proteins that are integrated into the plasma membrane. These proteins are not static, and can be moved to the cell's interior through a process called endocytosis. Some will subsequently be routed back to the cell surface and reused, and others will be degraded. There are grave consequences if the balance between recycling and degradation is derailed. In this issue, Ketel et al.1 (page 408) define a molecular mechanism that underpins the decision to direct cargo for recycling.

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Figure 1: Phospholipids direct membrane sorting.

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Authors and Affiliations

  1. Tamas Balla is in the Program for Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.,

    Tamas Balla

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  1. Tamas Balla
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Correspondence to Tamas Balla.

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Balla, T. Lipid code for membrane recycling. Nature 529, 292–293 (2016). https://doi.org/10.1038/nature16868

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