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Metabolism

Inflammation keeps old mice healthy

Immune cells called regulatory T cells accumulate in fat during ageing. The anti-inflammatory activity of these cells worsens age-associated defects in metabolism, in contrast to its effect in obesity. See Letter p.137

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Figure 1: Regulatory T cells impair metabolic regulation in old fat.

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References

  1. Osborn, O. & Olefsky, J. M. Nature Med. 18, 363–374 (2012).

    CAS  Article  PubMed  Google Scholar 

  2. Bapat, S. P. et al. Nature 528, 137–141 (2015).

    ADS  CAS  Article  PubMed  Google Scholar 

  3. Feuerer, M. et al. Nature Med. 15, 930–939 (2009).

    CAS  Article  PubMed  Google Scholar 

  4. Winer, S. et al. Nature Med. 15, 921–929 (2009).

    CAS  Article  PubMed  Google Scholar 

  5. Kolodin, D. et al. Cell Metab. 21, 543–557 (2015).

    CAS  Article  PubMed  Google Scholar 

  6. Cipolletta, D., Cohen, P., Spiegelman, B. M., Benoist, C. & Mathis, D. Proc. Natl Acad. Sci. USA 112, 482–487 (2015).

    ADS  CAS  Article  PubMed  Google Scholar 

  7. Cipolletta, D. et al. Nature 486, 549–553 (2012).

    ADS  CAS  Article  PubMed  Google Scholar 

  8. Vasanthakumar, A. et al. Nature Immunol. 16, 276–285 (2015).

    CAS  Article  Google Scholar 

  9. Lumeng, C. N. et al. J. Immunol. 187, 6208–6216 (2011).

    CAS  Article  PubMed  Google Scholar 

  10. Brestoff, J. R. et al. Nature 519, 242–246 (2015).

    ADS  CAS  Article  PubMed  Google Scholar 

  11. Lee, M.-W. et al. Cell 160, 74–87 (2015).

    CAS  Article  PubMed  Google Scholar 

  12. Lumeng, C. N. & Saltiel, A. R. J. Clin. Invest. 121, 2111–2117 (2011).

    CAS  Article  PubMed  Google Scholar 

  13. Wernstedt Asterholm, I. et al. Cell Metab. 20, 103–118 (2014).

    CAS  Article  PubMed  Google Scholar 

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Correspondence to Ivan Maillard or Alan R. Saltiel.

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Maillard, I., Saltiel, A. Inflammation keeps old mice healthy. Nature 528, 44–46 (2015). https://doi.org/10.1038/nature15648

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