Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Organ-seeking vesicles

An analysis reveals that cancer cells remotely prepare distant sites for tumour spread in an organ-specific manner, by deploying organ-seeking extracellular vesicles. See Article p.329

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Paving the way for organ-specific metastasis.


  1. See all news & views


  1. Paget, S. Lancet 1, 571–573 (1889).

    Article  Google Scholar 

  2. Fidler, I. J. Nature Rev. Cancer 3, 453–458 (2003).

    ADS  CAS  Article  Google Scholar 

  3. Nguyen, D. X., Bos, P. D. & Massagué, J. Nature Rev. Cancer 9, 274–284 (2009).

    CAS  Article  Google Scholar 

  4. Hoshino, A. et al. Nature 527, 329–335 (2015).

    ADS  CAS  Article  Google Scholar 

  5. Peinado, H. et al. Nature Med. 18, 883–891 (2012).

    CAS  Article  Google Scholar 

  6. Lötvall, J. et al. J. Extracell. Vesicles 3, 26913 (2014).

    Article  Google Scholar 

  7. Colombo, M., Raposo, G. & Théry, C. Annu. Rev. Cell Dev. Biol. 30, 255–289 (2014).

    CAS  Article  Google Scholar 

  8. Rak, J. Front. Pharmacol. 4, 21 (2013).

    Article  Google Scholar 

  9. Hood, J. L., San, R. S. & Wickline, S. A. Cancer Res. 71, 3792–3801 (2011).

    CAS  Article  Google Scholar 

  10. Poste, G. & Nicolson, G. L. Proc. Natl Acad. Sci. USA 77, 399–403 (1980).

    ADS  CAS  Article  Google Scholar 

  11. Kaplan, R. N. et al. Nature 438, 820–827 (2005).

    ADS  CAS  Article  Google Scholar 

  12. Costa-Silva, B. et al. Nature Cell Biol. 17, 816–826 (2015).

    CAS  Article  Google Scholar 

  13. Steeg, P. S., Camphausen, K. A. & Smith, Q. R. Nature Rev. Cancer 11, 352–363 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Janusz Rak.

Related audio

Related links

Related links

Related links in Nature Research

Cancer: Diagnosis by extracellular vesicles

Cancer: The complex seeds of metastasis

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rak, J. Organ-seeking vesicles. Nature 527, 312–314 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing