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Qin et al. reply

Nature volume 525, pages E2–E3 (2015)Cite this article

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replying to J. S. Bajaj, N. S. Betrapally & P. M. Gillevet Nature 525, 10.1038/nature14851 (2015)

In the accompanying Comment1, a concern expressed by Bajaj et al. is that diagnostics of liver cirrhosis by microbiome analysis that we report2 may be mainly due to the microbiome alterations in decompensated patients (DP). To address it we tested how accurately compensated patients (CP) can be diagnosed by microbiome analysis. Two slightly different criteria of identifying these were used, based on absence of ascites and hepatic encephalopathy (n = 54) and absence of ascites only (n = 57).

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References

  1. Bajaj, J. S., Betrapally, N. S. & Gillevet, P. M. Decompensated cirrhosis and microbiome interpretation. Nature 525 http://dx.doi.org/10.1038/nature14851 (2015)

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Author notes

  1. Nan Qin and Emmanuelle Le Chatelier: These authors contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China

    Nan Qin, Jing Guo & Lanjuan Li

  2. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, 310003, China

    Nan Qin & Lanjuan Li

  3. Metagenopolis, Institut National de la Recherche Agronomique, Jouy en Josas, 78350, France

    Emmanuelle Le Chatelier, Edi Prifti & S. Dusko Ehrlich

  4. King’s College London, Centre for Host-Microbiome Interactions, Dental Institute Central Office, Guy’s Hospital, London Bridge, SE1 9RT, London, UK

    S. Dusko Ehrlich

Authors
  1. Nan Qin
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  2. Emmanuelle Le Chatelier
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  3. Jing Guo
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  5. Lanjuan Li
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  6. S. Dusko Ehrlich
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Qin, N., Le Chatelier, E., Guo, J. et al. Qin et al. reply. Nature 525, E2–E3 (2015). https://doi.org/10.1038/nature14852

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