Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Decompensated cirrhosis and microbiome interpretation

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Microbiota distribution between compensated and decompensated cirrhotic subjects.

References

  1. Schuppan, D. & Afdhal, N. H. Liver cirrhosis. Lancet 371, 838–851 (2008)

    CAS  Article  Google Scholar 

  2. Qin, N. et al. Alterations of the human gut microbiome in liver cirrhosis. Nature 513, 59–64 (2014)

    ADS  CAS  Article  Google Scholar 

  3. Bajaj, J. S. et al. Linkage of gut microbiome with cognition in hepatic encephalopathy. Am. J. Physiol. Gastrointest. Liver Physiol. 302, G168–G175 (2012)

    CAS  Article  Google Scholar 

  4. Chen, Y. et al. Characterization of fecal microbial communities in patients with liver cirrhosis. Hepatology 54, 562–572 (2011)

    Article  Google Scholar 

  5. Bajaj, J. S. et al. Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 303, G675–G685 (2012)

    CAS  Article  Google Scholar 

  6. Chavez-Tapia, N. C., Tellez-Avila, F. I., Garcia-Leiva, J. & Valdovinos, M. A. Use and overuse of proton pump inhibitors in cirrhotic patients. Med. Sci. Monit. 14, CR468–CR472 (2008)

    PubMed  Google Scholar 

  7. Bajaj, J. S. et al. A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy. Metab. Brain Dis. 27, 205–215 (2012)

    CAS  Article  Google Scholar 

  8. Bajaj, J. S. et al. Altered profile of human gut microbiome is associated with cirrhosis and its complications. J. Hepatol. 60, 940–947 (2014)

    CAS  Article  Google Scholar 

  9. Bajaj, J. S. et al. Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy. PLoS ONE 8, e60042 (2013)

    ADS  CAS  Article  Google Scholar 

  10. Kanno, T. et al. Gastric acid reduction leads to an alteration in lower intestinal microflora. Biochem. Biophys. Res. Commun. 381, 666–670 (2009)

    CAS  Article  Google Scholar 

  11. Bajaj, J. S. et al. Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function. Am. J. Physiol. Gastrointest. Liver Physiol. 307, G951–G957 (2014)

    CAS  Article  Google Scholar 

  12. Segata, N. et al. Metagenomic biomarker discovery and explanation. Genome Biol. 12, R60 (2011)

    Article  Google Scholar 

  13. Gillevet, P., Sikaroodi, M., Keshavarzian, A. & Mutlu, E. A. Quantitative assessment of the human gut microbiome using multitag pyrosequencing. Chem. Biodivers. 7, 1065–1075 (2010)

    CAS  Article  Google Scholar 

  14. Zhang, Z. et al. Large-scale survey of gut microbiota associated with MHE via 16S rRNA-based pyrosequencing. Am. J. Gastroenterol. 108, 1601–1611 (2013)

    ADS  CAS  Article  Google Scholar 

  15. Elkrief, L. et al. Diabetes mellitus is an independent prognostic factor for major liver-related outcomes in patients with cirrhosis and chronic hepatitis C. Hepatology 60, 823–831 (2014)

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

J.S.B. supervised the patient recruitment, sample collection and clinical analysis. He was also involved in the data interpretation, analysis and drafting of the manuscript. N.S.B. was involved in data analysis and interpretation. P.M.G. was responsible for data analysis, interpretation and drafting of the manuscript. All authors participated in the critical revision of the manuscript.

Corresponding author

Correspondence to Jasmohan S. Bajaj.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bajaj, J., Betrapally, N. & Gillevet, P. Decompensated cirrhosis and microbiome interpretation. Nature 525, E1–E2 (2015). https://doi.org/10.1038/nature14851

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature14851

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing