Overexpression of the enzyme cytidine deaminase allows the incorporation of abnormally modified nucleotides into DNA, leading to cell death. This discovery might point the way to treating some cancers. See Letter p.114
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References
Vander Heiden, M. G. Nature Rev. Drug Discov. 10, 671–684 (2011).
Zauri, M. et al. Nature 524, 114–118 (2015).
Li, E. & Zhang, Y. Cold Spring Harb. Perspect. Biol. 6, a019133 (2014).
Jekunen, A., Puukka, M. & Vilpo, J. Biochem. Pharmacol. 32, 1165–1168 (1983).
Vilpo, J. A. & Vilpo, L. M. Mutat. Res. 286, 217–220 (1993).
Ross, D. T. et al. Nat. Genet. 24, 227–235 (2000).
Barretina, J. et al. Nature 483, 603–607 (2012).
Shin, G. et al. Cancer Inform. 10, 149–157 (2011).
Brooks, S. C., Adhikary, S., Rubinson, E. H. & Eichman, B. F. Biochim. Biophys. Acta 1834, 247–271 (2013).
Gad, H. et al. Nature 508, 215–221 (2014).
Huber, K. V. et al. Nature 508, 222–227 (2014).
Abbruzzese, J. L. et al. J. Clin. Oncol. 9, 491–498 (1991).
Rahib, L. et al. Cancer Res. 74, 2913–2921 (2014).
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Sivanand, S., Wellen, K. Salvaging the genome. Nature 524, 40–41 (2015). https://doi.org/10.1038/nature14638
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DOI: https://doi.org/10.1038/nature14638
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DNA methylome and single-cell transcriptome analyses reveal CDA as a potential druggable target for ALK inhibitor–resistant lung cancer therapy
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