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Cancer

Precise control of localized signals

The tumour-suppressor protein PTEN is mostly found in the cell cytoplasm, tethered to endosome vesicles. This localization regulates the enzyme's activity towards specific lipids and influences its control of cell growth.

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Figure 1: Endosomal PTEN in PIP3 control.

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Correspondence to Vuk Stambolic.

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Stambolic, V. Precise control of localized signals. Nature 522, 38–40 (2015). https://doi.org/10.1038/nature14531

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