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Cancer

Antibodies regulate antitumour immunity

Boosting the T cells that mediate anticancer immune responses is a therapeutic goal. But T cells do not work alone — B cells and the antibodies they produce can both trigger and suppress the response. See Letters p.94 & p.99

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Figure 1: Two opposing roles for B cells in cancer immunology.

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References

  1. Vesely, M. D., Kershaw, M. H., Schreiber, R. D. & Smyth, M. J. Annu. Rev. Immunol. 29, 235–271 (2011).

    Article  CAS  PubMed  Google Scholar 

  2. Chen, D. S. & Mellman, I. Immunity 39, 1–10 (2013).

    Article  Google Scholar 

  3. Galluzzi, L. et al. Oncotarget 5, 12472–12508 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Zitvogel, L., Galluzzi, L., Smyth, M. J. & Kroemer, G. Immunity 39, 74–88 (2013).

    Article  CAS  PubMed  Google Scholar 

  5. Hannani, D. et al. Cell Death Differ. 21, 50–58 (2014).

    Article  CAS  PubMed  Google Scholar 

  6. Carmi, Y. et al. Nature 521, 99–104 (2015).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  7. Shalapour, S. et al. Nature 521, 94–98 (2015).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  8. Tesniere, A. et al. Oncogene 29, 482–491 (2010).

    Article  CAS  PubMed  Google Scholar 

  9. Kroemer, G., Galluzzi, L., Kepp, O. & Zitvogel, L. Annu. Rev. Immunol. 31, 51–72 (2013).

    Article  CAS  PubMed  Google Scholar 

  10. Gerdes, C. A. et al. Clin. Cancer Res. 19, 1126–1138 (2013).

    Article  CAS  PubMed  Google Scholar 

Download references

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Correspondence to Guido Kroemer.

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Zitvogel, L., Kroemer, G. Antibodies regulate antitumour immunity. Nature 521, 35–37 (2015). https://doi.org/10.1038/nature14388

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