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A big-hearted molecule

Blockade of the enzyme PDE9 prevents degradation of the molecule cyclic GMP, which has been shown to protect against heart failure. The finding indicates that PDE9 inhibition might be a drug target for treating this condition. See Letter p.472

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Figure 1: Three heart-protecting regulatory circuits.


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Correspondence to Michaela Kuhn.

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Kuhn, M. A big-hearted molecule. Nature 519, 416–417 (2015).

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