Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Molecular biology

Entry signals control development

Certain structural elements allow messenger RNAs not usually processed by the protein-synthesis apparatus to be translated. It now seems that they also control the expression of genes involved in embryonic development. See Article p.33

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Regulating the translation of certain Hox genes.


  1. Mirsky, A. E. & Ris, H. J. Gen. Physiol. 34, 451–462 (1951).

    Article  CAS  Google Scholar 

  2. Mallo, M. & Alonso, C. R. Development 140, 3951–3963 (2013).

    Article  CAS  Google Scholar 

  3. Xue, S. et al. Nature 517, 33–38 (2015).

    Article  CAS  ADS  Google Scholar 

  4. Hershey, J. W. B., Sonenberg, N. & Mathews, M. B. Cold Spring Harb. Perspect. Biol. 4, a011528 (2012).

    Article  Google Scholar 

  5. Sonenberg, N. & Hinnebusch, A. G. Cell 136, 731–745 (2009).

    Article  CAS  Google Scholar 

  6. Mokrejš, M. et al. Nucleic Acids Res. 38 (Suppl. 1), D131–D136 (2010).

    Article  Google Scholar 

  7. Alexander, T., Nolte, C. & Krumlauf, R. Annu. Rev. Cell Dev. Biol. 25, 431–456 (2009).

    Article  CAS  Google Scholar 

  8. Kondrashov, N. et al. Cell 145, 383–397 (2011).

    Article  CAS  Google Scholar 

  9. Jenner, L. et al. Curr. Opin. Struct. Biol. 22, 759–767 (2012).

    Article  CAS  Google Scholar 

  10. Giaever, G. et al. Nature 418, 387–391 (2002).

    Article  CAS  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Jonathan D. Dinman.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Dinman, J. Entry signals control development. Nature 517, 24–25 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing