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Cancer

Metastasis risk after anti-macrophage therapy

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Blocking the activity of macrophages may delay the spread of cancer. But new findings show that these immune cells can rapidly rebound to tumours after therapy withdrawal, accelerating lethal metastasis in mice. See Letter p.130

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Figure 1: Monocyte rebounds after therapy.

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Correspondence to Michele De Palma.

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Keklikoglou, I., De Palma, M. Metastasis risk after anti-macrophage therapy. Nature 515, 46–47 (2014). https://doi.org/10.1038/nature13931

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