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Lipid landscapes and pipelines in membrane homeostasis

Nature volume 510, pages 4857 (05 June 2014) | Download Citation

Abstract

The lipid composition of cellular organelles is tailored to suit their specialized tasks. A fundamental transition in the lipid landscape divides the secretory pathway in early and late membrane territories, allowing an adaptation from biogenic to barrier functions. Defending the contrasting features of these territories against erosion by vesicular traffic poses a major logistical problem. To this end, cells evolved a network of lipid composition sensors and pipelines along which lipids are moved by non-vesicular mechanisms. We review recent insights into the molecular basis of this regulatory network and consider examples in which malfunction of its components leads to system failure and disease.

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Acknowledgements

Work in the authors laboratories is supported by the European Union (MC-ITN Sphingonet Project 289278 to J.C.H.), the Deutsche Forschungsgemeinschaft (SFB944-P14 to J.C.H.) and the National Institutes of Health (grant GM071041 to A.K.M.).

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Affiliations

  1. Fachbereich Biologie/Chemie, University of Osnabrück, Barbarastrasse 13, 49076 Osnabrück, Germany.

    • Joost C.M. Holthuis
  2. Membrane Biochemistry & Biophysics, Bijvoet Center for Biomolecular Research and Institute of Biomembranes, Utrecht University, the Netherlands.

    • Joost C.M. Holthuis
  3. Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

    • Anant K. Menon

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The authors declare no competing financial interests.

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Correspondence to Joost C.M. Holthuis or Anant K. Menon.

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