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Neurodegenerative diseases

G-quadruplex poses quadruple threat

Multiplication of repetitive DNA sequences is often the cause of neurodegenerative diseases. A four-stranded structure has been found to form in one such expansion in the gene C9orf72, altering gene function in four ways. See Article p.195

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Figure 1: G-quadruplex formation in nucleic-acid strands.

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Correspondence to J. Paul Taylor.

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Taylor, J. G-quadruplex poses quadruple threat. Nature 507, 175–177 (2014). https://doi.org/10.1038/nature13067

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