In advanced age, the stem cells responsible for muscle regeneration switch from reversible quiescence to irreversible senescence. Targeting a driver of senescence revives muscle stem cells and restores regeneration. See Article p.316
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Li, M., Belmonte, J. Genetic rejuvenation of old muscle. Nature 506, 304–305 (2014). https://doi.org/10.1038/nature13058
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DOI: https://doi.org/10.1038/nature13058
