Rings in biologically active molecules confer rigidity that helps the molecules to bind strongly and selectively to their targets. A ring-forming mechanism has been identified that involves a biochemically unusual reaction. See Letter p.124
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Notes
*This article and the paper under discussion4 were published online on 18 September 2013.
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Townsend, C. Modular biosynthesis branches out. Nature 502, 44–45 (2013). https://doi.org/10.1038/nature12562
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DOI: https://doi.org/10.1038/nature12562
