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Systems biology

Metabolite turns master regulator

The phenomenon of catabolite repression enables microorganisms to use their favourite carbon source first. New work reveals α-ketoacids as key effectors of this process, with their levels regulating gene expression. See Article p.301

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Figure 1: Regulation of cAMP levels by carbon and nitrogen availability.


  1. *This article and the paper under discussion3 were published online on 7 August 2013.


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Correspondence to Joshua D. Rabinowitz.

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Rabinowitz, J., Silhavy, T. Metabolite turns master regulator. Nature 500, 283–284 (2013).

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