Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Developmental biology

Segmentation within scale

Irrespective of an organism's size, the proportional sizes of its parts remain constant. An experimental model reveals size-dependent adjustment of segment formation and gene-expression oscillations in vertebrates. See Letter p.101

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Oscillating waves of gene expression in culture.


  1. 1.

    *This article and the paper under discussion1 were published online on 19 December 2012.


  1. 1

    Lauschke, V. M., Tsiairis, C. D., François, P. & Aulehla, A. Nature 493, 101–105 (2013).

    ADS  Article  Google Scholar 

  2. 2

    Pourquié, O . Cell 145, 650–663 (2011).

    Article  Google Scholar 

  3. 3

    Oates, A. C., Morelli, L. G. & Ares, S. Development 139, 625–639 (2012).

    CAS  Article  Google Scholar 

  4. 4

    Saga, Y. Curr. Opin. Genet. Dev. 22, 331–338 (2012).

    CAS  Article  Google Scholar 

  5. 5

    Cooke, J. Nature 254, 196–199 (1975).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Cooke, J. Nature 290, 775–778 (1981).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Cooke, J. & Zeeman, E. C. J. Theor. Biol. 58, 455–476 (1976).

    CAS  Article  Google Scholar 

  8. 8

    Meinhardt, H. Models of Biological Pattern Formation (Academic, 1982).

    Google Scholar 

  9. 9

    Delaune, E. A., François, P., Shih, N. P. & Amacher, S. L. Dev. Cell 23, 995–1005 (2012).

    CAS  Article  Google Scholar 

  10. 10

    Soroldoni, D. & Oates, A. C. Curr. Opin. Genet. Dev. 21, 600–605 (2011).

    CAS  Article  Google Scholar 

  11. 11

    Ben-Zvi, D., Pyrowolakis, G., Barkai, N. & Shilo, B.-Z. Curr. Biol. 21, 1391–1396 (2011).

    CAS  Article  Google Scholar 

  12. 12

    Ben-Zvi, D. & Barkai, N. Proc. Natl Acad. Sci. USA 107, 6924–6929 (2010).

    ADS  CAS  Article  Google Scholar 

  13. 13

    Gregor, T., Bialek, W., de Ruyter van Steveninck, R. R., Tank, D. W. & Wieschaus, E. F. Proc. Natl Acad. Sci. USA 102, 18403–18407 (2005).

    ADS  CAS  Article  Google Scholar 

  14. 14

    Hamaratoglu, F., de Lachapelle, A. M., Pyrowolakis, G., Bergmann, S. & Affolter, M. PLoS Biol. 9, e1001182 (2011).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Naama Barkai.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Barkai, N., Shilo, BZ. Segmentation within scale. Nature 493, 32–33 (2013).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing